来自瑞香的新型脲酶抑制剂。

Novel urease inhibitors from Daphne oleoids.

作者信息

Ayaz Muhammad, Lodhi Muhammad Arif, Riaz Muhammad, Ul-haq Azhar, Malik Abdul, Choudhary M Iqbal

机构信息

HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan.

出版信息

J Enzyme Inhib Med Chem. 2006 Oct;21(5):527-9. doi: 10.1080/14756360600774470.

DOI:10.1080/14756360600774470

PMID:17194022

Abstract

Phytochemical investigations on the chloroform and ethyl acetate soluble fractions of the roots of the Daphne oleoids led to the isolation of the coumarin glycosides 1-6. Compound 5 with IC50 values 22.05 and 26.30 microM repectively, was found to be the most active of these compounds when screened against Bacillus pasteurii and jack bean urease enzymes in a concentration-dependent fashion.

摘要

对瑞香狼毒根的氯仿和乙酸乙酯可溶部分进行植物化学研究，分离得到了香豆素苷1 - 6。在以浓度依赖方式针对巴氏芽孢杆菌和刀豆脲酶进行筛选时，发现化合物5的IC50值分别为22.05和26.30微摩尔，是这些化合物中活性最强的。