一种来自大戟属植物的新型巴氏芽孢杆菌脲酶抑制剂。

A new Bacillus pasteurii urease inhibitor from Euphorbia decipiens.

作者信息

Lodhi Muhammad Arif, Hussain Javid, Abbasi Muhammad Athar, Jassbi Amir Reza, Choudhary Muhammad Iqbal, Ahmad Viqar Uddin

机构信息

Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

出版信息

J Enzyme Inhib Med Chem. 2006 Oct;21(5):531-5. doi: 10.1080/14756360600586072.

DOI:10.1080/14756360600586072

PMID:17194023

Abstract

Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. and Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 +/- 0.7 microM.

摘要

从大戟科植物拟大戟（Euphorbia decipiens Boiss. and Buhse）中分离得到的具有半日花醇型骨架的二萜酯3,7,15-三-O-乙酰基-5-O-烟酰基-13,14-二羟基半日花醇（1）对巴氏芽孢杆菌脲酶的抑制作用与分子对接结果一致，呈非竞争性。抑制常数（Ki）值为117.40±0.7微摩尔。