内源性大麻素对免疫的调控——神经保护的新机制？
Immune control by endocannabinoids - new mechanisms of neuroprotection?
作者信息
Ullrich Oliver, Merker Katrin, Timm Johanna, Tauber Svantje
机构信息
Institute of Immunology, Medical Faculty, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
出版信息
J Neuroimmunol. 2007 Mar;184(1-2):127-35. doi: 10.1016/j.jneuroim.2006.11.018. Epub 2006 Dec 28.
The endocannabinoid system consists of cannabinoid receptors, their endogenous ligands and enzymes for synthesis and degradation of endocannabinoids and represents a local messenger system within and between the nervous and immune system. Apparently, the endocannabinoid system is involved in immune control and neuoprotection. In this review, we discuss possible mechanisms of immune control by endocannabinoids, which include the modulation of innate immunity, effects on cytokin networks, downregulation of adaptive immune response and apoptosis in immune cells.
内源性大麻素系统由大麻素受体、其内源性配体以及用于内源性大麻素合成和降解的酶组成，是神经和免疫系统内部及之间的一种局部信使系统。显然，内源性大麻素系统参与免疫控制和神经保护。在本综述中，我们讨论了内源性大麻素免疫控制的可能机制，包括先天免疫的调节、对细胞因子网络的影响、适应性免疫反应的下调以及免疫细胞中的细胞凋亡。
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