Zhang Yang-de, Lu Xiao-lin, Li Nian-feng
Institute of Biomedical Engineering, Central South University, Xiangya Road, Kai-Fu District, Changsha, Hunan 410008, PR China.
Med Hypotheses. 2007;68(6):1258-61. doi: 10.1016/j.mehy.2006.07.062. Epub 2006 Dec 28.
In order to control HIV pandemic, many vaccines are invented. Although none first verified its efficacy in clinic, we hypothesize that HIV vaccine based on poliovirus is potential to develop the promising one, because it can elicit the broad immune response including the main mucosal, humoral and cellular reaction. However, the viral neural virulence is one major concern. The attenuated Sabin strain is a better candidate. While partial poliovirus genes are replaced by HIV antigen genes, the defective interfering particle will fail to produce progeny virions, which may further ensure its security. Although the vaccinal immune efficacy was verified in some similar animal experiments based on poliovirus to express the exogenous genes, more animal and clinical immune trials about HIV-poliovirus chimeric minireplicons are to be carried out and the hypotheses are to be validated.
为了控制艾滋病大流行，人们研发了许多疫苗。尽管尚无一种疫苗首先在临床上验证其疗效，但我们推测，基于脊髓灰质炎病毒的艾滋病疫苗有潜力成为一种有前景的疫苗，因为它能引发广泛的免疫反应，包括主要的黏膜、体液和细胞反应。然而，病毒的神经毒力是一个主要问题。减毒的萨宾株是一个更好的候选者。当脊髓灰质炎病毒的部分基因被艾滋病抗原基因取代时，缺陷干扰颗粒将无法产生子代病毒粒子，这可能进一步确保其安全性。尽管在一些基于脊髓灰质炎病毒表达外源基因的类似动物实验中验证了疫苗的免疫效果，但关于艾滋病 - 脊髓灰质炎病毒嵌合微型复制子的更多动物和临床免疫试验仍有待开展，相关假设也有待验证。
