Yasuda K, Nagashima K, Murayama N, Yamanishi T, Tojo M, Shimazaki J
Department of Urology, School of Medicine, Chiba University, Japan.
Urol Int. 1991;47 Suppl 1:43-7. doi: 10.1159/000282248.
External urethral function was urodynamically examined in 13 patients with benign prostatic hypertrophy (BPH) associated with chronic urinary retention and in 5 volunteers. Prevoiding drop in external urethral sphincter pressure was noted in all the volunteers, whereas it was not found in 6 of the 13 cases of BPH. Bladder neck opening pressure was higher in these 6 cases (p less than 0.05). After administration of phentolamine, prevoiding drop was noted in 5 of these 6 cases, and bladder neck opening pressure decreased so much that there was no significant intergroup difference. The above results mean that the increase in alpha-adrenergic receptors makes the prostate, which has been already hypertrophied, less elastic, inhibiting external urinary sphincter function.
对13例伴有慢性尿潴留的良性前列腺增生（BPH）患者和5名志愿者进行了尿道外括约肌功能的尿动力学检查。所有志愿者均出现排尿前尿道外括约肌压力下降，而13例BPH患者中有6例未出现这种情况。这6例患者的膀胱颈开放压力较高（p<0.05）。给予酚妥拉明后，这6例患者中有5例出现排尿前压力下降，且膀胱颈开放压力下降幅度很大，以致两组间无显著差异。上述结果表明，α-肾上腺素能受体增加使已增生的前列腺弹性降低，抑制尿道外括约肌功能。
