Harthmann Angela D, De Angelis Kátia, Costa Luciana Parente, Senador Danielle, Schaan Beatriz D, Krieger Eduardo Moacyr, Irigoyen Maria-Cláudia
Hypertension Unit, Heart Institute (InCor), University of São Paulo, Medical School, Av. Enéas de Carvalho Aguiar 44, São Paulo, SP 05403-000, Brazil.
Auton Neurosci. 2007 May 30;133(2):115-20. doi: 10.1016/j.autneu.2006.10.004. Epub 2006 Dec 28.
We investigated the effect of exercise training on blood pressure, heart rate, and arterial baro- and chemoreflex sensitivity in diabetic rats (streptozotocin, 50 mg/kg iv). Male Wistar rats (251+/-10 g) were divided into 4 groups (n=8, each group): sedentary normotensive (SC), sedentary diabetic (SD), trained normotensive (TC), and trained diabetic (TD). Trained groups underwent exercise training on a treadmill (10 weeks). Exercise training induced resting bradycardia (340+/-5 vs. 316+/-8 bpm) and improvement in baroreflex tachycardic response (3.4+/-0.31 vs. 2.7+/-0.06 bpm/mmHg in SC) and chemoreflex bradycardic (145+/-12 vs. 78+/-7 bpm in SC) and pressor (49+/-5 vs. 22+/-3 mmHg in SC) responses in control rats. Diabetic-induced hypotension (SC: 107+/-2 vs. SD: 93+/-2 mmHg) and bradycardia (SC: 340+/-5 vs. SD: 276+/-7 bpm) were reversed by exercise training. Baroreflex tachycardic and bradycardic responses impaired in SD rats (SD: 2.1+/-0.18 and 1.3+/-0.08 vs. SC: 2.7+/-0.06 and 1.3+/-0.08 bpm/mmHg) were enhanced in TD rats (2.5+/-0.1 and 1.7+/-0.06 bpm/mmHg). Chemoreflex bradycardic and pressor responses, attenuated in SD rats (23+/-9 bpm and 7+/-1 mmHg) in relation to SC rats, were improved by exercise (TD: 84+/-15 bpm and 32+/-5 mmHg). The improvement in arterial baro- and chemoreflex-mediated control of circulation in trained control and diabetic rats reinforces the role of exercise in the management of cardiovascular risk in healthy and diabetic individuals.
我们研究了运动训练对糖尿病大鼠（静脉注射链脲佐菌素，50 mg/kg）血压、心率以及动脉压力感受性反射和化学感受性反射敏感性的影响。雄性Wistar大鼠（251±10 g）被分为4组（每组n = 8）：久坐的正常血压组（SC）、久坐的糖尿病组（SD）、运动训练的正常血压组（TC）和运动训练的糖尿病组（TD）。运动训练组在跑步机上进行运动训练（10周）。运动训练使对照组大鼠出现静息性心动过缓（340±5对316±8次/分钟），压力感受性反射心动过速反应得到改善（SC组为3.4±0.31对2.7±0.06次/分钟/毫米汞柱），化学感受性反射心动过缓（SC组为145±12对78±7次/分钟）和升压反应（SC组为49±5对22±3毫米汞柱）也得到改善。运动训练逆转了糖尿病诱导的低血压（SC组：107±2对SD组：93±2毫米汞柱）和心动过缓（SC组：340±5对SD组：276±7次/分钟）。SD大鼠中受损的压力感受性反射心动过速和心动过缓反应（SD组：2.1±0.18和1.3±0.08对SC组：2.7±0.06和1.3±0.08次/分钟/毫米汞柱）在TD大鼠中得到增强（2.5±0.1和1.7±0.06次/分钟/毫米汞柱）。与SC大鼠相比，SD大鼠中减弱的化学感受性反射心动过缓和升压反应（23±9次/分钟和7±1毫米汞柱）通过运动得到改善（TD组：84±15次/分钟和32±5毫米汞柱）。运动训练的正常血压组和糖尿病大鼠中动脉压力感受性反射和化学感受性反射介导的循环控制的改善，强化了运动在健康个体和糖尿病个体心血管风险管理中的作用。
