Mallet Vincent, Blanchard Pierre, Verkarre Virginie, Vallet-Pichard Anaïs, Fontaine Hélène, Lascoux-Combe Caroline, Pol Stanislas
Université Paris-Descartes, France.
AIDS. 2007 Jan 11;21(2):187-92. doi: 10.1097/QAD.0b013e3280119e47.
To describe and explain the syndrome of HIV-associated cryptogenic liver disease in eight consecutive patients suffering from portal hypertension.
The study was undertaken at a liver disease centre in Paris and involved eight of 97 consecutive HIV-infected patients presenting abnormal liver function tests and/or symptomatic portal hypertension of unknown origin. Serology, pathology, and liver function tests were performed.
A clear nodular architecture corresponding to nodular regenerative hyperplasia was observed in seven patients and suggested in one, based on the presence of sinusoidal dilatation in a clinical context of portal hypertension, without overt liver disease.
Nodular regenerative hyperplasia appears to be a new cause of portal hypertension in HIV-infected patients. This syndrome can be of critical importance as patients can be exposed to the significant complications of portal hypertension and to refractory ascites which may require liver transplantation.
描述并解释8例连续性门静脉高压伴人类免疫缺陷病毒（HIV）相关隐源性肝病患者的综合征。
该研究在巴黎的一个肝病中心开展，纳入了97例连续性HIV感染患者中8例肝功能检查异常和/或出现不明原因的症状性门静脉高压的患者。进行了血清学、病理学和肝功能检查。
7例患者观察到与结节性再生性增生相符的清晰结节结构，1例根据门静脉高压临床背景下存在窦性扩张提示有该结构，均无明显肝病。
结节性再生性增生似乎是HIV感染患者门静脉高压的一个新病因。该综合征可能至关重要，因为患者可能面临门静脉高压的严重并发症以及可能需要肝移植的难治性腹水。
