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Salvage therapy with amprenavir, lopinavir and ritonavir is durably potent in HIV-infected patients in virological failure: 1-year results.

作者信息

Raguin Gilles, Poizat Gwendoline, Morand-Joubert Laurence, Taburet Anne-Marie, Le Tiec Clotilde, Clavel François, Chêne Geneviève, Girard Pierre-Marie

机构信息

Département de Medecine, Hôpital Croix-St-Simon, France.

出版信息

AIDS. 2007 Jan 11;21(2):241-3. doi: 10.1097/QAD.0b013e3280118d6a.

DOI:10.1097/QAD.0b013e3280118d6a
PMID:17197818
Abstract

We report the results of the extended follow-up at one year of a randomized trial evaluating the virological efficacy of a salvage therapy combining lopinavir and amprenavir with either 200 or 400 mg/day ritonavir, along with optimized nucleoside reverse transcriptase inhibitors, in patients carrying multidrug-resistant isolates. The combination of amprenavir, lopinavir and ritonavir (400 mg/day) is durably potent, yielding a sustained virological response (HIV RNA < 50 copies) in 39% of cases.

摘要

相似文献

1
Salvage therapy with amprenavir, lopinavir and ritonavir is durably potent in HIV-infected patients in virological failure: 1-year results.
AIDS. 2007 Jan 11;21(2):241-3. doi: 10.1097/QAD.0b013e3280118d6a.
2
Salvage therapy with amprenavir, lopinavir and ritonavir 200 mg/d or 400 mg/d in HIV-infected patients in virological failure.在病毒学治疗失败的HIV感染患者中，使用安普那韦、洛匹那韦和利托那韦进行挽救治疗，利托那韦剂量为每日200毫克或400毫克。
Antivir Ther. 2004 Aug;9(4):615-25.
3
Mutations at codons 54 and 82 of HIV protease predict virological response of HIV-infected children on salvage lopinavir/ritonavir therapy.HIV蛋白酶第54和82密码子处的突变可预测接受挽救性洛匹那韦/利托那韦治疗的HIV感染儿童的病毒学反应。
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4
Virological success of lopinavir/ritonavir salvage regimen is affected by an increasing number of lopinavir/ritonavir-related mutations.洛匹那韦/利托那韦挽救治疗方案的病毒学成功受到越来越多与洛匹那韦/利托那韦相关突变的影响。
Antivir Ther. 2003 Jun;8(3):209-14.
5
Efficacy and tolerability of a fosamprenavir-ritonavir-based versus a lopinavir-ritonavir-based antiretroviral treatment in 82 therapy-naïve patients with HIV-1 infection.82例初治HIV-1感染患者中，基于福沙那韦-利托那韦与基于洛匹那韦-利托那韦的抗逆转录病毒治疗的疗效和耐受性比较
Int J STD AIDS. 2008 Aug;19(8):541-4. doi: 10.1258/ijsa.2008.007322.
6
Lopinavir/ritonavir monotherapy or plus zidovudine and lamivudine in antiretroviral-naive HIV-infected patients.洛匹那韦/利托那韦单药治疗或联合齐多夫定和拉米夫定用于初治的HIV感染患者。
AIDS. 2008 Jan 30;22(3):385-93. doi: 10.1097/QAD.0b013e3282f3f16d.
7
Virological response to salvage therapy in HIV-infected persons carrying the reverse transcriptase K65R mutation.携带逆转录酶K65R突变的HIV感染者对挽救疗法的病毒学反应。
Antivir Ther. 2007;12(8):1175-83.
8
Interactions between amprenavir and the lopinavir-ritonavir combination in heavily pretreated patients infected with human immunodeficiency virus.安普那韦与洛匹那韦-利托那韦组合在接受大量预处理的人类免疫缺陷病毒感染患者中的相互作用。
Clin Pharmacol Ther. 2004 Apr;75(4):310-23. doi: 10.1016/j.clpt.2003.12.013.
9
Lopinavir-ritonavir monotherapy versus lopinavir-ritonavir and two nucleosides for maintenance therapy of HIV.洛匹那韦-利托那韦单药疗法与洛匹那韦-利托那韦及两种核苷类药物用于HIV维持治疗的比较
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Predictive value of HIV-1 protease genotype and virtual phenotype on the virological response to lopinavir/ritonavir-containing salvage regimens.HIV-1蛋白酶基因型和虚拟表型对含洛匹那韦/利托那韦挽救治疗方案病毒学应答的预测价值
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Brief Report: Significant Decreases in Both Total and Unbound Lopinavir and Amprenavir Exposures During Coadministration: ACTG Protocol A5143/A5147s Results.简要报告：联合给药期间洛匹那韦和安普那韦的总暴露量及游离暴露量均显著降低：艾滋病临床试验组A5143/A5147s方案结果
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