O'Reilly Fiona, Traywick Carmen, Pennie Michelle L, Foster Jovonne K, Chen Suephy C
Department of Dermatology, Vanderbilt University, Nashville, Tennessee, USA.
Dermatol Surg. 2006 Dec;32(12):1480-5. doi: 10.1111/j.1524-4725.2006.32356.x.
Solid organ transplant recipients on high doses of immunosuppression are at increased risk for the development of nonmelanoma skin cancer (NMSC).
The objective was to assess the possible factors impacting quality of life (QOL) in solid organ transplant recipients.
Patients were seen in a dermatology clinic integrated within the transplant center at a university-based hospital. One anxiety questionnaire and three QOL questionnaires were administered to each patient. A regression model was used to determine possible predictors of anxiety and lower QOL.
The baseline scores on the QOL instruments and anxiety questionnaire indicate poor organ-specific and general QOL as well as high levels of anxiety. Time since transplant was predictive of lower QOL as measured by Skindex-16 (p<.01). While not significant, number of NMSCs correlated with higher anxiety as measured by the STAI (p=.055).
While transplant patients enjoy longer survival, the quality of the extended life has room for improvement. Future studies will determine how QOL changes over time as these patients develop more numerous and aggressive skin cancers. Intervention with regular screening may not only lessen morbidity associated with skin cancer but may improve overall QOL in the posttransplant period.
接受高剂量免疫抑制治疗的实体器官移植受者发生非黑色素瘤皮肤癌（NMSC）的风险增加。
评估影响实体器官移植受者生活质量（QOL）的可能因素。
在一家大学附属医院移植中心内的皮肤科诊所对患者进行诊治。对每位患者发放一份焦虑问卷和三份生活质量问卷。采用回归模型确定焦虑和较低生活质量的可能预测因素。
生活质量量表和焦虑问卷的基线评分表明，器官特异性和总体生活质量较差，焦虑水平较高。移植后的时间是Skindex-16测量的较低生活质量的预测因素（p<0.01）。虽然不显著，但非黑色素瘤皮肤癌的数量与状态特质焦虑问卷（STAI）测量的较高焦虑相关（p=0.055）。
虽然移植患者的生存期延长，但延长生命的质量仍有改善空间。未来的研究将确定随着这些患者发生更多、更具侵袭性的皮肤癌，生活质量如何随时间变化。定期筛查进行干预不仅可以减轻与皮肤癌相关的发病率，还可能改善移植后时期的总体生活质量。
