Hoshi Senji, Sasaki Mituharu, Muto Akinori, Suzuki Kenichi, Kobayashi Takashi, Tukigi Masaaki, Ono Kunio, Sugano Osamu, Saso Shunichi
Department of Urology and Pathology, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Int J Urol. 2007 Jan;14(1):79-81. doi: 10.1111/j.1442-2042.2006.01600.x.
Carcinosarcoma of the bladder is an unusual malignancy characterized by an intimate admixture of malignant epithelial elements (carcinoma) and malignant soft tissue elements (sarcoma). To our knowledge, almost 80 cases have been reported, usually as case reports or small series. Patient with carcinosarcoma usually present with a high stage malignancy. Cystectomy or transurethral resection is the preferred treatment, often followed by radiation therapy, although prognosis is very bad. We herein report a case of carcinosarcoma of bladder obtained pathologically complete response by neoadjuvant chemoradiotherapy. She now shows no evidence of disease 30 months after the operation. To our knowledge, it is the first case where urinary bladder carcinosarcoma obtained a pathologically complete response by chemoradiotherapy.
膀胱癌肉瘤是一种罕见的恶性肿瘤，其特征是恶性上皮成分（癌）和恶性软组织成分（肉瘤）紧密混合。据我们所知，几乎已有80例相关报道，通常为病例报告或小系列研究。患有癌肉瘤的患者通常表现为高分期恶性肿瘤。膀胱切除术或经尿道切除术是首选治疗方法，术后常接着进行放射治疗，尽管预后很差。我们在此报告一例经新辅助放化疗后病理完全缓解的膀胱癌肉瘤病例。术后30个月，她目前没有疾病迹象。据我们所知，这是首例经放化疗后病理完全缓解的膀胱癌肉瘤病例。
