促动力蛋白：一对新型调节肽。
The prokineticins: a novel pair of regulatory peptides.
作者信息
Zhou Qun-Yong
机构信息
Department of Pharmacology, University of California, Irvine, California 92697, USA.
出版信息
Mol Interv. 2006 Dec;6(6):330-8. doi: 10.1124/mi.6.6.6.
Abstract
Secreted peptides play broad regulatory roles in brain function and elsewhere in the body. Prokineticins are a pair of newly identified regulatory peptides that signal through two highly homologous G protein-coupled receptors. Prokineticins possess a unique structural motif of five disulfide bonds and a completely conserved N-terminal hexapeptide sequence that is essential to biological activity. Diverse biological functions, including roles in development and cell differentiation, have been assigned to the prokineticins. A network of genes, subject to various transcriptional factors, may functionally converge on the prokineticins as regulatory targets.
摘要
分泌肽在脑功能及身体其他部位发挥广泛的调节作用。促动力蛋白是一对新发现的调节肽，它们通过两个高度同源的G蛋白偶联受体发出信号。促动力蛋白具有由五个二硫键组成的独特结构基序以及对生物活性至关重要的完全保守的N端六肽序列。促动力蛋白具有多种生物学功能，包括在发育和细胞分化中的作用。一个受各种转录因子调控的基因网络可能在功能上汇聚于促动力蛋白作为调控靶点。
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