McAllister Laura A, McCormick Rosemary A, James Karen M, Brand Stephen, Willetts Nigel, Procter David J
Department of Chemistry, The Joseph Black Building, The University of Glasgow, Glasgow G12 8QQ, Scotland.
Chemistry. 2007;13(4):1032-46. doi: 10.1002/chem.200601429.
A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles.
基于一种新的普默勒尔环化过程的氟相环化捕获策略，能够快速构建带有标记的杂环骨架。通过包括钯催化交叉偶联在内的多种方法，可以方便地对氟相杂环支架进行修饰。氟相标签的无痕还原裂解或氧化裂解以及进一步衍生化，完善了一种用于高通量氟相合成多种氮杂环的策略。
