Aoki Yuko, Umezawa Naoki, Asano Yuko, Hatano Keiichiro, Yano Yuki, Kato Nobuki, Higuchi Tsunehiko
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
Bioorg Med Chem. 2007 Nov 15;15(22):7108-15. doi: 10.1016/j.bmc.2007.07.035. Epub 2007 Aug 22.
Heterocycles have been modified in various ways in the search for new functions, but few examples are known of crown ethers incorporating heterocycles in macro-ring systems. Here we report a simple and versatile synthesis of crown ether-bearing heterocycles. An acylurea moiety in the heterocycles is efficiently transformed to 'crown ether' of various ring sizes. The products included a Ca(2+)-selective fluoroionophore. Our simple methodology is expected to provide many novel functional heterocyclic compounds, including fluoroionophores and candidate pharmaceuticals.
为了寻找新功能，杂环已通过多种方式进行了修饰，但在大环体系中含有杂环的冠醚实例却很少见。在此，我们报道了一种简单且通用的含冠醚杂环的合成方法。杂环中的酰脲部分能有效地转化为各种环大小的“冠醚”。产物包括一种钙离子选择性氟离子载体。我们这种简单的方法有望提供许多新型功能性杂环化合物，包括氟离子载体和候选药物。
