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[植物ABC转运蛋白——具有传统的家族]

[Plant ABC transporters--the family with tradition].

作者信息

Jasiński Michał, Figlerowicz Marek

机构信息

Institute of Bioorganic Chemistry, Polish Academy of Sciences, 12/14 Z. Noskowskiego St., 61 704 Poznań, Poland.

出版信息

Postepy Biochem. 2006;52(3):296-302.

Abstract

ATP binding cassette (ABC) transporters, which are found in all species, are known mainly for their ability to confer drug resistance. They have been thoroughly studied in mammals, where they became the center of interest for clinical reasons related to the resistance of tumor cells to chemotherapy treatment. Less is known about plant members of the ABC family, however, growing number of reports on their role in different physiological processes attract attention. The vacuolar ABC transporters in plants characterized to date are involved in the intracellular sequestration of cytotoxins (e.g. herbicides), as well as the products of endogenous metabolism like chlorophyll catabolites. Others localized within plasma membrane are active in the transport of secondary metabolites or phytohormones. Finally certain transporters are present in cell organelles and play a role in such processes as P oxidation. Here, we briefly introduce these proteins, and describe structural characteristic and physiological aspect of their activity in a plant cell.

摘要

ATP结合盒(ABC)转运蛋白存在于所有物种中,主要因其赋予耐药性的能力而闻名。它们在哺乳动物中得到了深入研究,由于肿瘤细胞对化疗产生耐药性的临床原因,它们成为了研究热点。然而,对于ABC家族的植物成员了解较少,不过,越来越多关于它们在不同生理过程中作用的报道引起了关注。迄今为止已鉴定的植物液泡ABC转运蛋白参与细胞毒素(如除草剂)的细胞内隔离,以及叶绿素分解代谢产物等内源性代谢产物的隔离。其他定位于质膜的转运蛋白则在次生代谢产物或植物激素的运输中发挥作用。最后,某些转运蛋白存在于细胞器中,并在诸如P氧化等过程中发挥作用。在此,我们简要介绍这些蛋白质,并描述它们在植物细胞中的结构特征和生理活性方面。

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