乳腺癌中肿瘤蛋白p53诱导核蛋白1（TP53INP1）表达降低。
Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma.
作者信息
Ito Yasuhiro, Motoo Yoshiharu, Yoshida Hiroshi, Iovanna Juan Lucio, Takamura Yuuki, Miya Akihiro, Kuma Kanji, Miyauchi Akira
机构信息
Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011, Japan.
出版信息
Anticancer Res. 2006 Nov-Dec;26(6B):4391-5.
BACKGROUND
Tumor protein p53-induced nuclear protein 1 (TP53INP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, TP53INP1 expression in human breast carcinoma was investigated.
MATERIALS AND METHODS
TP53INP1 and aberrant p53 expression were investigated immunohistochemically in 81 cases of breast carcinoma.
RESULTS
Diffuse and intense TP53INP1 expression was observed in the normal mammary gland. Decreased TP53INP1 expression was found in 45 cases (55.6%) of breast carcinoma. The TP53INP1 expression level was inversely linked to tumor size, positive lymph node metastasis, high histological grade and aberrant p53 expression.
CONCLUSION
Decreased expression of TP53INP1 is involved in breast carcinoma progression.
背景
肿瘤蛋白p53诱导的核蛋白1（TP53INP1）是一种应激诱导蛋白，在细胞周期停滞和p53介导的细胞凋亡中发挥作用。本研究调查了TP53INP1在人乳腺癌中的表达情况。
材料与方法
采用免疫组织化学方法检测81例乳腺癌组织中TP53INP1和异常p53的表达。
结果
在正常乳腺组织中观察到弥漫性且强烈的TP53INP1表达。45例（55.6%）乳腺癌组织中TP53INP1表达降低。TP53INP1表达水平与肿瘤大小、阳性淋巴结转移、高组织学分级及异常p53表达呈负相关。
结论
TP53INP1表达降低与乳腺癌进展有关。
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