[大鼠乙醇摄入量与性功能之间的关系]

[Relationship between ethanol intake and sexual function in rats].

作者信息

Gan Xiu-guo, An Rui-hua, Wang Yong-quan

机构信息

Department of Urology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.

出版信息

Zhonghua Nan Ke Xue. 2006 Dec;12(12):1099-101.

PMID:17201256

Abstract

OBJECTIVE

To investigate the relationship between the intake of ethanol and sexual function of rats.

METHODS

Sixty adult male Wistar rats were randomly divided into five groups: the control, 10% , 20% , 30% and 40 ethanol groups, which received. . 9% sodium chloride, 10% , 20% , 30% and 40% ethanol solutions respectively at a dose of 2 ml through gastric tubes once a day. Three months later, we observed the effects of ethanol on the sexual function of the rats by their sexual behaviors, the number of apomorphine-induced penile erections, and the content of testosterone in the serum and nitric oxide synthase ( NOS) in the penis.

RESULTS

Compared with the control group, the number of apomorphine-induced penile erections in the 10% and 20% ethanol groups was not inhibited significantly (P > 0.05), but the latent period of mounting and intromission in the 10% ethanol group was prolonged and the sexual behaviors in the 20% ethanol group were inhibited except the latent period of ejaculation. The sexual behaviors and the number of apomorphine-induced penile erections of the 30% and 40% ethanol groups were inhibited significantly (P < 0.05). Testosterone in the serum and NOS activity in the penis of the experimental groups were reduced (Pat < 0.05).

CONCLUSION

An adequate volume of ethanol does not induce sexual dysfunction in rats, but long term and excessive intake of ethanol may cause penile erectile dysfunction.

摘要

目的

探讨乙醇摄入量与大鼠性功能之间的关系。

方法

将60只成年雄性Wistar大鼠随机分为五组：对照组、10%乙醇组、20%乙醇组、30%乙醇组和40%乙醇组，分别通过胃管每日给予1次2 ml的0.9%氯化钠溶液、10%、20%、30%和40%乙醇溶液。三个月后，通过观察大鼠性行为、阿扑吗啡诱导阴茎勃起的次数、血清睾酮含量及阴茎一氧化氮合酶（NOS）含量，来观察乙醇对大鼠性功能的影响。

结果

与对照组相比，10%和20%乙醇组阿扑吗啡诱导阴茎勃起的次数无明显抑制（P>0.05），但10%乙醇组骑跨和插入潜伏期延长，20%乙醇组除射精潜伏期外性行为受到抑制。30%和40%乙醇组的性行为及阿扑吗啡诱导阴茎勃起的次数均受到明显抑制（P<0.05）。实验组血清睾酮及阴茎NOS活性降低（P<0.05）。