Gan Xiu-guo, An Rui-hua, Wang Yong-quan
Department of Urology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
Zhonghua Nan Ke Xue. 2006 Dec;12(12):1099-101.
To investigate the relationship between the intake of ethanol and sexual function of rats.
Sixty adult male Wistar rats were randomly divided into five groups: the control, 10% , 20% , 30% and 40 ethanol groups, which received. . 9% sodium chloride, 10% , 20% , 30% and 40% ethanol solutions respectively at a dose of 2 ml through gastric tubes once a day. Three months later, we observed the effects of ethanol on the sexual function of the rats by their sexual behaviors, the number of apomorphine-induced penile erections, and the content of testosterone in the serum and nitric oxide synthase ( NOS) in the penis.
Compared with the control group, the number of apomorphine-induced penile erections in the 10% and 20% ethanol groups was not inhibited significantly (P > 0.05), but the latent period of mounting and intromission in the 10% ethanol group was prolonged and the sexual behaviors in the 20% ethanol group were inhibited except the latent period of ejaculation. The sexual behaviors and the number of apomorphine-induced penile erections of the 30% and 40% ethanol groups were inhibited significantly (P < 0.05). Testosterone in the serum and NOS activity in the penis of the experimental groups were reduced (Pat < 0.05).
An adequate volume of ethanol does not induce sexual dysfunction in rats, but long term and excessive intake of ethanol may cause penile erectile dysfunction.
探讨乙醇摄入量与大鼠性功能之间的关系。
将60只成年雄性Wistar大鼠随机分为五组：对照组、10%乙醇组、20%乙醇组、30%乙醇组和40%乙醇组，分别通过胃管每日给予1次2 ml的0.9%氯化钠溶液、10%、20%、30%和40%乙醇溶液。三个月后，通过观察大鼠性行为、阿扑吗啡诱导阴茎勃起的次数、血清睾酮含量及阴茎一氧化氮合酶（NOS）含量，来观察乙醇对大鼠性功能的影响。
与对照组相比，10%和20%乙醇组阿扑吗啡诱导阴茎勃起的次数无明显抑制（P>0.05），但10%乙醇组骑跨和插入潜伏期延长，20%乙醇组除射精潜伏期外性行为受到抑制。30%和40%乙醇组的性行为及阿扑吗啡诱导阴茎勃起的次数均受到明显抑制（P<0.05）。实验组血清睾酮及阴茎NOS活性降低（P<0.05）。
适量乙醇不会诱发大鼠性功能障碍，但长期过量摄入乙醇可能导致阴茎勃起功能障碍。
