Da Cunha Claudio, Silva Marcio H C, Wietzikoski Samantha, Wietzikoski Evellyn C, Ferro Marcelo M, Kouzmine Ivana, Canteras Newton S
Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Behav Neurosci. 2006 Dec;120(6):1279-84. doi: 10.1037/0735-7044.120.6.1279.
The substantia nigra pars compacta (SNc) and the dorsal striatum are often considered to be necessary for stimulus-response (S-R) habit learning, whereas the dorsal hippocampus is considered to be necessary for relational (declarative) memory. Spatial learning is a kind of relational learning that occurs when a rat is released from different locations (variable start) in a water maze to find a submerged platform that is kept in a constant location. However, when the rat is always released from the same starting position (constant start), it can learn to find the platform oriented by a fixed configuration of cues, that is, by S-R learning. To test the critical role of the SNc in S-R and relational learning, the authors tested adult male Wistar rats, sham-operated or with a lesion in the SNc, in these 2 versions of the water maze task. The SNc lesion was induced by bilateral intranigral infusion of 0.5 micromol 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine. Although the SNc-lesioned rats learned the variable-start version as effectively as sham rats did, they were significantly impaired in learning the constant-start version of the task.
黑质致密部（SNc）和背侧纹状体通常被认为是刺激-反应（S-R）习惯学习所必需的，而背侧海马体被认为是关系性（陈述性）记忆所必需的。空间学习是一种关系性学习，当大鼠从水迷宫中的不同位置（可变起始点）被释放以找到位于固定位置的水下平台时就会发生。然而，当大鼠总是从相同的起始位置（固定起始点）被释放时，它可以通过固定的线索配置来学习找到平台，即通过S-R学习。为了测试SNc在S-R和关系性学习中的关键作用，作者在这两种版本的水迷宫任务中测试了成年雄性Wistar大鼠，这些大鼠要么是假手术，要么在SNc有损伤。SNc损伤是通过双侧脑内注射0.5微摩尔1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的。尽管SNc损伤的大鼠学习可变起始点版本的效果与假手术大鼠一样好，但它们在学习任务的固定起始点版本时明显受损。
