Bhaskaran Shylesh, Santanam Nalini, Penumetcha Meera, Parthasarathy Sampath
Department of Pathology, Louisiana State University, Health Sciences Center, New Orleans, LA, USA.
J Med Food. 2006 Winter;9(4):487-90. doi: 10.1089/jmf.2006.9.487.
Diet has profound effects on the development of atherosclerosis. Fatty acid composition, antioxidants, and other components such as lignans have major effects on the atherosclerotic process. Sesame oil has both mono- and polyunsaturated fatty acid constituents in equal proportions. In addition, it also has high levels of numerous antioxidants and inducers of peroxisome proliferator-activated receptor. The objective of this study was to determine the anti-atherosclerotic effects of sesame oil. In this study, male low-density lipoprotein (LDL) receptor (LDLR) -/- mice were fed atherogenic diet or atherogenic diet reformulated with the same level of sesame oil (sesame oil diet). Plasma lipids and atherosclerotic lesions were quantified after 3 months of feeding. Sesame oil-containing diet significantly reduced the atherosclerotic lesion formation and plasma cholesterol, triglyceride, and LDL cholesterol levels in LDLR -/- mice. These findings suggest that sesame oil could inhibit atherosclerosis lesion formation effectively, perhaps because of the synergistic actions of fatty acid and nonsaponifiable components.
饮食对动脉粥样硬化的发展具有深远影响。脂肪酸组成、抗氧化剂以及木脂素等其他成分对动脉粥样硬化进程有重大影响。芝麻油中单不饱和脂肪酸和多不饱和脂肪酸成分比例相等。此外，它还含有大量抗氧化剂以及过氧化物酶体增殖物激活受体诱导剂。本研究的目的是确定芝麻油的抗动脉粥样硬化作用。在本研究中，给雄性低密度脂蛋白（LDL）受体（LDLR）基因敲除小鼠喂食致动脉粥样硬化饮食或用相同水平芝麻油重新配制的致动脉粥样硬化饮食（芝麻油饮食）。喂食3个月后对血浆脂质和动脉粥样硬化病变进行定量分析。含芝麻油的饮食显著减少了LDLR基因敲除小鼠的动脉粥样硬化病变形成以及血浆胆固醇、甘油三酯和低密度脂蛋白胆固醇水平。这些发现表明，芝麻油可能因其脂肪酸和不可皂化成分的协同作用而有效抑制动脉粥样硬化病变形成。
