Roberts Andrew, Parker Catherine, Grundy Irene, de Jonge-Levitan Lilian, Most Marlene, Ferguson James, Greenway Frank
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
J Med Food. 2006 Winter;9(4):579-81. doi: 10.1089/jmf.2006.9.579.
This study was designed to document the mechanism through which globin digest, a dietary herbal supplement, might cause weight loss by exploring possible fat malabsorption, calorie malabsorption, energy expenditure, and fat oxidation. Six healthy subjects were placed on an outpatient diet for 14 days and given a meal containing 40.9 g of fat on days 5 and 11, and stools were collected for 72 hours after each meal for analysis of fecal fat content. Four grams of globin digest was given with one meal and placebo with the other. In another separate study, six subjects were placed on a 100-g fat, weight-maintaining diet for 14 days. All food was prepared by the Pennington Center (Baton Rouge, LA) metabolic kitchen. Globin digest (2 g) or placebo was given with each of three meals per day, and stool was collected for calorie determinations during the last 72 hours of each week. Subjects received globin digest during one of the 2 weeks and placebo during the other. Resting metabolic rate and respiratory quotient were measured on the last day of each 1-week period. There was no increase in 72-hour fecal fat or fecal calories by bomb calorimetry during either of the studies. There was no difference in the respiratory quotient. Globin digest did result in an increase in resting metabolic rate. However, this increase was not statistically significant. Globin digest, if effective, does not cause weight loss or fat loss through fat malabsorption or a relative increase in fat oxidation. Future studies are needed to document the efficacy of globin digest for weight loss in humans before further mechanistic investigation is attempted.
本研究旨在通过探索可能的脂肪吸收不良、热量吸收不良、能量消耗和脂肪氧化，来记录膳食草药补充剂珠蛋白消化物可能导致体重减轻的机制。六名健康受试者接受了为期14天的门诊饮食，并在第5天和第11天给予一顿含有40.9克脂肪的餐食，每餐之后收集72小时的粪便以分析粪便脂肪含量。一顿餐食给予4克珠蛋白消化物，另一顿给予安慰剂。在另一项单独的研究中，六名受试者接受了为期14天的100克脂肪维持体重饮食。所有食物均由彭宁顿中心（路易斯安那州巴吞鲁日）代谢厨房制备。每天三餐每餐给予珠蛋白消化物（2克）或安慰剂，并在每周的最后72小时收集粪便以测定热量。受试者在两周中的一周接受珠蛋白消化物，另一周接受安慰剂。在每个1周周期的最后一天测量静息代谢率和呼吸商。在两项研究中的任何一项中，通过弹式量热法测定的72小时粪便脂肪或粪便热量均未增加。呼吸商没有差异。珠蛋白消化物确实导致静息代谢率增加。然而，这种增加在统计学上并不显著。珠蛋白消化物如果有效，不会通过脂肪吸收不良或脂肪氧化的相对增加导致体重减轻或脂肪减少。在尝试进行进一步的机制研究之前，需要未来的研究来证明珠蛋白消化物对人类体重减轻的疗效。
