Harrison Jodie M, Bertram Edward M, Ramshaw Ian A
Department of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Viral Immunol. 2006 Winter;19(4):593-601. doi: 10.1089/vim.2006.19.593.
4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8(+) T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8(+) T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.
4-1BB是肿瘤坏死因子受体（TNFR）超家族的成员，正逐渐成为一种重要的共刺激分子，尤其是在调节CD8(+) T细胞反应方面。通过4-1BB进行的共刺激，例如利用激动性抗4-1BB单克隆抗体，已在各种肿瘤模型中得到充分研究。然而，4-1BB也是抗病毒CD8(+) T细胞反应的重要调节因子。本综述总结了这些发现，并描述了4-1BB在增强抗病毒疫苗反应方面是如何开始得到应用的。
