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植物异源三聚体G蛋白复合体。

The plant heterotrimeric G-protein complex.

作者信息

Temple Brenda R S, Jones Alan M

机构信息

R. L. Juliano Structural Bioinformatics Core Facility, Departments of Biology and Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

出版信息

Annu Rev Plant Biol. 2007;58:249-66. doi: 10.1146/annurev.arplant.58.032806.103827.

Abstract

Heterotrimeric G-protein complexes couple extracellular signals via cell surface receptors to downstream enzymes called effectors. Heterotrimeric G-protein complexes, together with their cognate receptors and effectors, operate at the apex of signal transduction. In plants, the number of G-protein complex components is dramatically less than in other multicellular eukaryotes. An understanding of how multiple signals propagate transduction through the G-protein node can be found in the unique structural and kinetic properties of the plant heterotrimeric G-protein complex. This review addresses these unique features and speculates on why the repertoire of G-protein signaling elements is dramatically simpler than that in all other multicellular eukaryotes.

摘要

异源三聚体G蛋白复合物通过细胞表面受体将细胞外信号与称为效应器的下游酶偶联起来。异源三聚体G蛋白复合物与其同源受体和效应器一起,在信号转导的顶端发挥作用。在植物中,G蛋白复合物成分的数量比其他多细胞真核生物中的要少得多。通过植物异源三聚体G蛋白复合物独特的结构和动力学特性,可以了解多种信号如何通过G蛋白节点进行转导。本综述阐述了这些独特特征,并推测了为何G蛋白信号元件库比所有其他多细胞真核生物中的要简单得多。

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