Gutiérrez-Alvarez A M
Faculty of Medicine, Research Office, Universidad del Rosario, Bogotá, Colombia.
Acta Psychiatr Scand. 2007 Jan;115(1):80-1. doi: 10.1111/j.1600-0447.2006.00856.x.
Yawning has been described in relation to drugs such as serotonin reuptake inhibitors, levodopa, dopamine agonists, MAO B inhibitor, morphine, methadone, buprenorphine, dextromethorphan, benzodiazepine, lidocaine, and flecaine. This is a report of two patients, on long-term escitalopram therapy (more than 8 weeks) with stable dosing, who presented excessive yawning. Escitalopram is widely used in major depressive disorder and generalized anxiety disorder.
A clinical description of two cases.
Two females (62 and 59 years old, respectively) developed excessive daytime yawning. It was not associated with sedation or a feeling of needing sleep. The dosage was reduced and yawning disappeared some hours later. The patients' depression did not recur.
Yawning has been described in relation to different selective serotonin reuptake inhibitors and remitted following their discontinuation; it is interesting that the reported yawning in these two cases disappeared with the reduction of dosage, rather than the interruption of treatment.
打哈欠与多种药物有关，如5-羟色胺再摄取抑制剂、左旋多巴、多巴胺激动剂、单胺氧化酶B抑制剂、吗啡、美沙酮、丁丙诺啡、右美沙芬、苯二氮卓类、利多卡因和氟卡尼。本文报告了两名长期服用艾司西酞普兰（治疗时间超过8周且剂量稳定）的患者出现过度打哈欠的情况。艾司西酞普兰广泛用于治疗重度抑郁症和广泛性焦虑症。
对两例病例进行临床描述。
两名女性患者（分别为62岁和59岁）出现白天过度打哈欠。这与镇静或困倦感无关。减少药物剂量后，数小时内打哈欠症状消失。患者的抑郁症状未复发。
不同的选择性5-羟色胺再摄取抑制剂与打哈欠有关，停药后打哈欠症状缓解；有趣的是，这两例报告中的打哈欠症状随着剂量减少而消失，而非治疗中断。
