Kiya K, Uozumi T, Kurisu K, Hotta T, Ogasawara H, Sugiyama K
Department of Neurosurgery, Hiroshima University School of Medicine.
Neurol Med Chir (Tokyo). 1991 Apr;31(4):194-8. doi: 10.2176/nmc.31.194.
The outcomes in 32 cases of histologically diagnosed primary central nervous system lymphoma were investigated. The 1-, 2-, and 5-year survival rates were 54, 36, and 8%, respectively. Good outcome was indicated by extensive surgical removal with 50-Gy irradiation and lower ages. 61% of patients receiving radiation therapy suffered recurrence within 1 year. The incidence of multiple lesions increased at recurrence. These lesions were almost all remote from the initial site in the brain, occurring more frequently in the central part of the supratentorial regions near the ventricle. Multiple lesions recurred more rapidly than single lesions. Longer survival times were indicated by a long tumor-free period after initial treatment. Extensive surgical removal results in long survival times for patients with a localized single tumor in the early stage. Radiochemotherapy should be given as part of the initial treatment.
对32例经组织学诊断的原发性中枢神经系统淋巴瘤的预后进行了研究。1年、2年和5年生存率分别为54%、36%和8%。广泛手术切除联合50Gy放疗及较低年龄提示预后良好。接受放疗的患者中有61%在1年内复发。复发时多发病灶的发生率增加。这些病灶几乎都远离脑内的初始部位，更频繁地发生在幕上区域靠近脑室的中央部分。多发病灶比单发病灶复发更快。初始治疗后无瘤期长提示生存时间长。广泛手术切除可使早期局限性单发肿瘤患者获得较长的生存时间。放化疗应作为初始治疗的一部分。
