父母创伤后应激障碍对其成年子女地塞米松给药后皮质醇反应的影响。
Effects of parental PTSD on the cortisol response to dexamethasone administration in their adult offspring.
作者信息
Yehuda Rachel, Blair William, Labinsky Ellen, Bierer Linda M
机构信息
Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, 130 West Kingsbridge Rd., Bronx, NY 10468, USA.
出版信息
Am J Psychiatry. 2007 Jan;164(1):163-6. doi: 10.1176/ajp.2007.164.1.163.
OBJECTIVE
The authors used a low-dose dexamethasone suppression test to examine the effect of a PTSD risk factor, parental PTSD, on cortisol negative feedback inhibition in adult offspring of Holocaust survivors with PTSD (N=13) versus without PTSD (N=12) as well as a comparison group of offspring whose parents had no Holocaust exposure (N=16).
METHOD
Blood samples were obtained at 8:00 a.m. for the determination of baseline cortisol. Participants ingested 0.5 mg of dexamethasone at 11:00 p.m., and blood samples were obtained again at 8:00 a.m. the following day.
RESULTS
Enhanced cortisol suppression in response to dexamethasone was associated primarily with parental PTSD status, with minimal contribution of subjects' own trauma-related symptoms.
CONCLUSIONS
Enhanced cortisol negative feedback inhibition may be associated with PTSD because it is related to the PTSD risk factor of parental PTSD.
目的
作者采用低剂量地塞米松抑制试验，研究创伤后应激障碍（PTSD）的一个风险因素——父母患PTSD，对有PTSD的大屠杀幸存者成年后代（N = 13）与无PTSD的大屠杀幸存者成年后代（N = 12）以及父母未经历大屠杀的后代对照组（N = 16）中皮质醇负反馈抑制的影响。
方法
上午8点采集血样以测定基础皮质醇水平。参与者于晚上11点摄入0.5毫克地塞米松，并于次日上午8点再次采集血样。
结果
地塞米松引起的皮质醇抑制增强主要与父母的PTSD状态有关，而受试者自身与创伤相关的症状影响极小。
结论
皮质醇负反馈抑制增强可能与PTSD有关，因为它与父母患PTSD这一PTSD风险因素相关。
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