Castro-Vale Ivone, van Rossum Elisabeth F C, Staufenbiel Sabine M, Severo Milton, Mota-Cardoso Rui, Carvalho Davide
Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal.
i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Psychiatry Investig. 2020 Oct;17(10):976-986. doi: 10.30773/pi.2020.0212. Epub 2020 Oct 6.
Posttraumatic stress disorder (PTSD) has been associated with lower circulating cortisol levels in specific subgroups, which have also been found in the offspring of people with PTSD. The analysis of hair cortisol concentrations (HCC) is a recent methodology which is used to assess long-term systemic cortisol levels. We aimed to study veterans with war-related lifetime PTSD and their respective offspring with regards to HCC. We also studied the influence of lifetime major depressive disorder (MDD), war experiences, and childhood adversities on HCC in these groups.
31 male veterans with PTSD and 28 without PTSD and 69 adult offspring were studied. HCC were quantified by liquid chromatography tandem-mass spectrometry.
No differences in HCC were found between veterans with and without PTSD, or between their respective offspring. Veterans without MDD showed a positive association between total war exposure and HCC. Veterans reporting more frequent childhood physical abuse had lower HCC. Veterans-with-PTSD's offspring with MDD had increased HCC compared to offspring without MDD. Offspring's exposure to more frequent childhood physical abuse was negatively associated with HCC in those without MDD.
HCC did not appear to constitute a marker of intergenerational heritage of war-related PTSD, except in the case of veteranswith-PTSD's offspring with MDD. Our data suggest that HCC is a marker of adult reported childhood physical abuse.
创伤后应激障碍（PTSD）与特定亚组中循环皮质醇水平降低有关，在PTSD患者的后代中也发现了这种情况。毛发皮质醇浓度（HCC）分析是一种用于评估长期全身皮质醇水平的最新方法。我们旨在研究患有与战争相关的终身PTSD的退伍军人及其各自的后代的HCC情况。我们还研究了终身重度抑郁症（MDD）、战争经历和童年逆境对这些人群HCC的影响。
研究了31名患有PTSD的男性退伍军人、28名未患PTSD的男性退伍军人以及69名成年后代。通过液相色谱串联质谱法定量HCC。
患有PTSD和未患PTSD的退伍军人之间，或他们各自的后代之间，HCC没有差异。没有MDD的退伍军人显示总战争暴露与HCC之间存在正相关。报告童年身体虐待更频繁的退伍军人HCC较低。患有PTSD的退伍军人的患有MDD的后代与未患MDD的后代相比，HCC有所增加。在没有MDD的人群中，后代遭受更频繁的童年身体虐待与HCC呈负相关。
除了患有PTSD的退伍军人的患有MDD的后代外，HCC似乎不构成与战争相关的PTSD代际遗传的标志物。我们的数据表明，HCC是成年人报告的童年身体虐待的标志物。
