女性的先天用手习惯与特定疾病死亡率

Innate handedness and disease-specific mortality in women.

作者信息

Ramadhani Made K, Elias Sjoerd G, van Noord Paulus A H, Grobbee Diederick E, Peeters Petra H M, Uiterwaal Cuno S P M

机构信息

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

Epidemiology. 2007 Mar;18(2):208-12. doi: 10.1097/01.ede.0000253923.68352.48.

DOI:10.1097/01.ede.0000253923.68352.48

PMID:17202907

Abstract

BACKGROUND

Left-handedness has been reported to be associated with reduced life expectancy, but the evidence is far from conclusive.

METHODS

We studied the association between innate handedness and total mortality, as well as cause-specific mortality, in a cohort of 12,178 middle-aged Dutch women who were followed for almost 13 years. The relation between handedness and mortality was analyzed using Cox regression in a case-cohort approach, in which a random sample of 1500 women was used to represent person-years under observation for the entire cohort.

RESULTS

During a median follow-up of 12.6 years, 252 women died. Hazard ratios comparing left-handed women with other women were 1.4 for all-cause mortality (95% confidence interval = 0.9-2.0), 1.7 for total cancer mortality (1.0-2.7), 2.0 for breast cancer mortality (0.8-4.6), 4.6 for colorectal cancer mortality (1.5-14.3), 1.3 mortality from diseases of the circulatory system (0.5-3.3), and 3.7 for cerebrovascular mortality (1.1-12.1), after adjusting for potential confounders (socioeconomic status, age, body mass index, and cigarette smoking status at study recruitment).

CONCLUSIONS

Left-handedness is associated with higher mortality in women.

摘要

背景

据报道，左利手与预期寿命缩短有关，但证据远非确凿。

方法

我们在一个由12178名荷兰中年女性组成的队列中进行研究，对她们进行了近13年的随访，以探讨先天利手与总死亡率以及特定病因死亡率之间的关联。采用病例队列研究方法，利用Cox回归分析利手与死亡率之间的关系，其中从1500名女性中随机抽样以代表整个队列的观察人年数。

结果

在中位随访期12.6年期间，有252名女性死亡。在调整潜在混杂因素（研究入组时的社会经济地位、年龄、体重指数和吸烟状况）后，左利手女性与其他女性相比的全因死亡率风险比为1.4（95%置信区间 = 0.9 - 2.0），总癌症死亡率风险比为1.7（1.0 - 2.7），乳腺癌死亡率风险比为2.0（0.8 - 4.6），结直肠癌死亡率风险比为4.6（1.5 - 14.3），循环系统疾病死亡率风险比为1.3（0.5 - 3.3），脑血管疾病死亡率风险比为3.7（1.1 - 12.1）。