含RGD寡肽包被表面对体外和体内骨形成的影响。

Influence of RGD-containing oligopeptide-coated surface on bone formation in vitro and in vivo.

作者信息

Kim Tae-Il, Lee Gene, Jang Jun-Hyeog, Chung Chong-Pyoung, Ku Young

机构信息

Department of Periodontology, Intellectual Biointerface Engineering Center, Seoul National University, Seoul, South Korea.

出版信息

Biotechnol Lett. 2007 Mar;29(3):359-63. doi: 10.1007/s10529-006-9262-9. Epub 2007 Jan 4.

DOI:10.1007/s10529-006-9262-9

PMID:17203344

Abstract

New bone formation on an RGD-containing oligopeptide-coated surface in vitro and in vivo was investigated. The surface showed two-fold higher osteoblastic cell adhesion and differentiation in vitro, and revealed statistically significant in vivo bone formation compared with the control (P < 0.05).

摘要

研究了含RGD的寡肽包被表面在体外和体内的新骨形成情况。该表面在体外显示出成骨细胞粘附和分化能力提高了两倍，并且与对照组相比，在体内显示出具有统计学意义的骨形成（P < 0.05）。