Meier F, Wessel G, Thiele R, Gottschild D, Brandstätt H
Department of Internal Medicine, Friedrich Schiller University, Jena-Lobeda, F.R.G.
Exp Pathol. 1991;42(4):257-63. doi: 10.1016/s0232-1513(11)80079-4.
As, after an stroke, the autoregulation of the cerebral vessels in the ischaemic region is disturbed to a high degree, it is, on principle, possible to improve the blood flow particularly in the zone surrounding the infarct (penumbra) by raising the systemic blood pressure. During a basic treatment with low-molecular dextrans (infukoll M40), 37 patients with an acute ischaemic cerebral stroke multiply underwent elevations in blood pressure up to systolic values of about 210 to 220 mmHg. A comparison with a control group (n = 44) who were treated with low-molecular dextrans revealed no differences in lethality on the 21st day after the stroke. However, a very good acute effect in terms of a short-term improvement was remarkable a result that is noteworthy also in future.
由于中风后缺血区域脑血管的自动调节功能受到高度干扰，原则上，通过提高全身血压，特别是在梗死灶周围区域（半暗带）改善血流是可能的。在用低分子右旋糖酐（英孚可M40）进行基础治疗期间，37例急性缺血性脑卒中患者多次将血压升高至收缩压约210至220 mmHg。与接受低分子右旋糖酐治疗的对照组（n = 44）相比，中风后第21天的死亡率没有差异。然而，在短期改善方面有非常好的急性效果，这一结果在未来也值得关注。
