Salemi Michele, Calogero Aldo E, Bosco Paolo, Castiglione Roberto, La Vignera Sandro, Borgione Eugenia, Rappazzo Giancarlo, Vicari Enzo
Section of Endocrinology, Andrology and Internal Medicine, Department of Biomedical Sciences, University of Catania, Catania, Italy.
Hum Cell. 2006 Aug;19(3):87-90. doi: 10.1111/j.1749-0774.2006.00014.x.
The function of SpanX proteins is unknown, evidence is accumulating to suggest their involvement in tumorigenesis. A locus in Xq27, where the SpanX gene family is located, has been associated with testicular germ cell tumor (TGCT) onset. Therefore, we evaluated the presence of SpanX mRNA in six TGCT cases by RT-PCR. The results showed that SpanX mRNA is present in TGCT, confirming transcriptional activity of these genes in such tumors.
SpanX蛋白的功能尚不清楚，但越来越多的证据表明它们参与肿瘤发生。位于Xq27（SpanX基因家族所在位置）的一个基因座已被证实与睾丸生殖细胞肿瘤（TGCT）的发病有关。因此，我们通过逆转录聚合酶链反应（RT-PCR）评估了6例TGCT病例中SpanX mRNA的存在情况。结果显示，TGCT中存在SpanX mRNA，证实了这些基因在这类肿瘤中的转录活性。
