Lunell N O, Garoff L, Grunewald C, Nisell H, Nylund L, Sarby B, Thornström S
Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, Sweden.
J Cardiovasc Pharmacol. 1991;18 Suppl 3:S37-40.
To assess the effect of isradipine on blood pressure, and uteroplacental and fetal blood flows in pregnancy-induced hypertension, 41 women with a diastolic blood pressure greater than or equal to 95 mm Hg were included in our study. Of these, 27 received isradipine 5 mg twice daily. Uteroplacental blood flow index was calculated from the activity-time curve of the very low radiation from the placenta after intravenous injection of 18.5 MBq indium-113m. Blood flow velocity was measured in the uterine and umbilical arteries, and fetal aorta, using the pulsed Doppler technique. Investigations were performed before and after 1 week of isradipine. A control group of 14 women was examined in the same way. The isradipine group showed a significant reduction in mean arterial pressure (from 117 to 112 mm Hg) whereas there was no change in the controls. Uteroplacental blood flow indices were similar before treatment in both groups and did not change during treatment. Furthermore, the pulsatility indices were the same in both groups at the first examination and also did not change. Isradipine had no adverse effects on the fetus. In conclusion, isradipine lowered blood pressure without altering uteroplacental or fetal blood flows.
为评估伊拉地平对妊娠高血压患者血压、子宫胎盘血流及胎儿血流的影响，我们纳入了41名舒张压大于或等于95mmHg的女性进行研究。其中，27名患者每日两次服用5mg伊拉地平。静脉注射18.5MBq铟-113m后，根据胎盘极低辐射的活性-时间曲线计算子宫胎盘血流指数。使用脉冲多普勒技术测量子宫动脉、脐动脉及胎儿主动脉的血流速度。在服用伊拉地平1周前后进行检查。以同样方式检查了14名女性作为对照组。伊拉地平组平均动脉压显著降低（从117mmHg降至112mmHg），而对照组无变化。两组治疗前子宫胎盘血流指数相似，治疗期间也未改变。此外，两组首次检查时搏动指数相同，且未发生变化。伊拉地平对胎儿无不良影响。总之，伊拉地平可降低血压，而不改变子宫胎盘或胎儿血流。
