Kantola I, Rauhala E, Erkinjuntti M, Mansury L
Department of Medicine, Turku University Hospital, Finland.
J Cardiovasc Pharmacol. 1991;18 Suppl 3:S41-5.
This was a comparison of the effects of isradipine and metoprolol on sleep apnea syndrome in 12 hypertensive men who were habitual snorers. Each patient received double-blind isradipine 1.25-2.5 mg twice daily or metoprolol 50-100 mg twice daily after a 4-week placebo period. Static charge-sensitive bed examination was performed during the placebo period and 5-7 weeks after starting treatment. The number of obstructive breathing patterns was increased by metoprolol in five patients, remained the same with isradipine in four, and was decreased by metoprolol in one patient and by isradipine in two. Obstructive patterns increased in the metoprolol group from 24 +/- 26% to 32 +/- 31% and decreased in the isradipine group from 21 +/- 23% to 19 +/- 25% (p less than 0.05, Mann-Whitney U test). Neither drug had a significant effect on blood pressure values. There was no significant difference in oxygen desaturation or in the amount of quiet sleep in either treatment group. On the basis of these results, it would appear that isradipine is more suitable than metoprolol for the treatment of hypertension in patients who are habitual snorers.
这是一项关于伊拉地平与美托洛尔对12名习惯性打鼾的高血压男性睡眠呼吸暂停综合征影响的比较研究。在为期4周的安慰剂期后，每位患者接受双盲治疗，每日两次服用1.25 - 2.5毫克伊拉地平或每日两次服用50 - 100毫克美托洛尔。在安慰剂期以及开始治疗后的5 - 7周进行静电荷敏感床检查。美托洛尔使5名患者的阻塞性呼吸模式数量增加，4名患者服用伊拉地平后该数量保持不变，1名患者服用美托洛尔后阻塞性呼吸模式数量减少，2名患者服用伊拉地平后减少。美托洛尔组阻塞性模式从24±26%增至32±31%，伊拉地平组从21±23%降至19±25%（曼-惠特尼U检验，p<0.05）。两种药物对血压值均无显著影响。两个治疗组在氧饱和度下降或安静睡眠时长方面均无显著差异。基于这些结果，对于习惯性打鼾的高血压患者，伊拉地平似乎比美托洛尔更适合用于治疗高血压。
