Risebro Catherine A, Riley Paul R
UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
ScientificWorldJournal. 2006 Apr 25;6:1862-80. doi: 10.1100/tsw.2006.316.
The formation of the ventricles of the heart involves numerous carefully regulated temporal events, including the initial specification and deployment of ventricular progenitors, subsequent growth and maturation of the ventricles through "ballooning" of chamber myocardium, the emergence of trabeculations, the generation of the compact myocardium, and the formation of the interventricular septum. Several genes have been identified through studies on mouse knockout and transgenic models, which have contributed to our understanding of the molecular events governing these developmental processes. Interpretation of these studies highlights the fact that even the smallest perturbation at any stage of ventricular development may lead to cardiac malformations that result in either early embryonic mortality or a manifestation of congenital heart disease.
心脏心室的形成涉及众多精确调控的时间性事件，包括心室祖细胞的初始特化与分布、随后通过心室心肌“膨胀”实现的心室生长与成熟、小梁的出现、致密心肌的生成以及室间隔的形成。通过对小鼠基因敲除和转基因模型的研究，已鉴定出多个基因，这些研究有助于我们理解调控这些发育过程的分子事件。对这些研究的解读凸显了这样一个事实，即心室发育任何阶段哪怕最微小的扰动都可能导致心脏畸形，进而导致早期胚胎死亡或先天性心脏病的表现。
