哈金斯基缺血评分在记忆门诊的应用：泰国经验。
Use of Hachinski Ischemic Score in the memory clinic: Thai experience.
作者信息
Siritho Sasitorn, Senanarong Vorapun, Nako Arpas, Chotinaiwattarakul Wattananchai, Jamjumrus Piyanuj, Udompunthuruk Suthipol, Poungvarin Niphon
机构信息
Division of Neurology, Department of Medicine, Faculty of Medicine, Siriraj Hopital, Mahidol University, Bangkok, Thailand.
出版信息
J Med Assoc Thai. 2006 Nov;89(11):1822-8.
BACKGROUND
The validity ofHachinski Ischemic Score (HIS) in differentiating between Alzheimer's disease (AD) and Vascular dementia (VaD) has been questioned and compared with the gold standard autopsy.
OBJECTIVE
To confirm that the HIS can be used to differentiate related VaD from AD in a Thai population.
MATERIAL AND METHOD
A prospective study of 398 patients who were attending the Memory Clinic, at Siriraj Hospital between January 2001 and October 2003.
RESULTS
The 214 patients, with a mean age of 71.15 + 10.20 years, were classified as AD, VaD or mixed dementia (AD with cerebrovascular disease) in proportion of 60.2%, 30.4%, and 9.3% respectively. The authors propose HIS at 5 as a cut off point to differentiate patients with AD and those with VaD or AD with cerebrovascular disease with sensitivity of 85.3% and specificity of 72.9%.
CONCLUSION
The HIS can be applied to differentiate dementia related vascular etiology from AD in a Thai population.
背景
哈金斯基缺血评分（HIS）在区分阿尔茨海默病（AD）和血管性痴呆（VaD）方面的有效性受到质疑，并与金标准尸检进行了比较。
目的
证实HIS可用于在泰国人群中区分相关的VaD和AD。
材料与方法
对2001年1月至2003年10月在诗里拉吉医院记忆门诊就诊的398例患者进行前瞻性研究。
结果
214例患者，平均年龄71.15±10.20岁，分别被分类为AD、VaD或混合性痴呆（伴有脑血管疾病的AD），比例分别为60.2%、30.4%和9.3%。作者提出以HIS为5作为区分AD患者与VaD或伴有脑血管疾病的AD患者的分界点，敏感性为85.3%，特异性为72.9%。
结论
HIS可用于在泰国人群中区分与血管病因相关的痴呆和AD。
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