Baillon Sarah, Muhommad Saquib, Marudkar Mangesh, Suribhatla Srinivas, Dennis Michael, Spreadbury Christine, Munro Dena, Lindesay James
Division of Psychiatry for the Elderly, Department of Psychiatry, University of Leicester, Leicester, UK.
Int J Geriatr Psychiatry. 2003 Jul;18(7):602-8. doi: 10.1002/gps.887.
To compare the performances of two matched groups of patients with Alzheimer's disease (AD) and vascular dementia (VaD) on a battery of neuropsychological tests.
325 patients attending a memory clinic were given a detailed multi-disciplinary diagnostic assessment, including a battery of neuropsychological tests administered by a psychologist and a speech and language therapist. The performances of two groups of patients meeting ICD-10 criteria for AD (n = 103) and VaD (n = 68) were compared, adjusting for age, gender, dementia severity and pre-morbid IQ. Patients with co-morbid depression and mixed AD+VaD were excluded.
After adjustment, the AD and VaD groups differed significantly on the Graded Naming Test (VaD superior), AMIPB Complex Design immediate and delayed recall (VaD superior), the Trail Making Test error score (Part B) (VaD superior), and Verbal Picture Description (VaD superior).
These findings support previous evidence that language function and non-verbal memory are selectively more impaired in AD. The better performance by VaD patients on the Trail Making Test (B) runs counter to previous suggestions that there is an excess of frontal executive dysfunction in this disorder. It may be that this test is more sensitive to the early impairment of concurrent manipulation of information in AD.
比较两组匹配的阿尔茨海默病（AD）患者和血管性痴呆（VaD）患者在一系列神经心理学测试中的表现。
对325名就诊于记忆门诊的患者进行了详细的多学科诊断评估，包括由心理学家和言语语言治疗师进行的一系列神经心理学测试。比较了两组符合ICD - 10标准的AD患者（n = 103）和VaD患者（n = 68）的表现，并对年龄、性别、痴呆严重程度和病前智商进行了调整。排除了合并抑郁症和AD + VaD混合型患者。
调整后，AD组和VaD组在分级命名测试（VaD表现更佳）、AMIPB复杂图形设计即时和延迟回忆（VaD表现更佳）、连线测验错误分数（B部分）（VaD表现更佳）以及言语图片描述（VaD表现更佳）方面存在显著差异。
这些发现支持了先前的证据，即语言功能和非言语记忆在AD中选择性地受到更严重的损害。VaD患者在连线测验（B）中表现更好，这与之前认为该疾病存在过多额叶执行功能障碍的观点相悖。可能是该测试对AD中信息同时处理的早期损害更敏感。
