从硒聚苯乙烯树脂固相合成连接杂环化合物。

Solid-phase synthesis of linked heterocycles from a selenopolystyrene resin.

作者信息

Huang Xian, Wang Yu-Guang

机构信息

Department of Chemistry, Zhejiang University (XixiCampus), Hangzhou 310028, P. R. China.

出版信息

J Comb Chem. 2007 Jan-Feb;9(1):121-30. doi: 10.1021/cc0600775.

DOI:10.1021/cc0600775

PMID:17206840

Abstract

A linked heterocycle library of isoxazoles, 1,2,3-triazoles, bicyclo[2.2.1]hepta-2,5-diene or 4-methylcyclohexa-1,3-diene and 1,2,4-oxadiazoles was prepared by solid-phase organic synthesis. Key steps on resin-bound selenium were electrophilic additions; 1,3-dipolar cycloaddition; Porco's two-step, one-pot condensation of amidoxime and carboxylate; and Diels-Alder reaction.

摘要

通过固相有机合成制备了异恶唑、1,2,3-三唑、双环[2.2.1]庚-2,5-二烯或4-甲基环己-1,3-二烯与1,2,4-恶二唑的连接杂环库。在树脂结合硒上的关键步骤包括亲电加成；1,3-偶极环加成；Porco的偕胺肟和羧酸盐的两步一锅法缩合；以及狄尔斯-阿尔德反应。