杂环核苷类似物的固相合成：从硒聚苯乙烯树脂合成与异恶唑、异恶唑啉和三唑相连的取代尿嘧啶。

Solid-phase synthesis of heterocyclic nucleoside analogues: substituted uracils tethered to isoxazoles, isoxazolines, and triazoles from a selenopolystyrene resin.

作者信息

Cao Jian, Huang Xian

机构信息

Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, P. R. China.

出版信息

J Comb Chem. 2008 Jul-Aug;10(4):526-33. doi: 10.1021/cc800034v. Epub 2008 Jun 14.

DOI:10.1021/cc800034v

PMID:18553984

Abstract

A heterocyclic nucleoside analogue library of uracils N1 tethered to isoxazoles, isoxazolines, and triazoles and uracil N3 tethered to isoxazolines and isoxazoles was constructed by solid-phase organic synthesis. This strategy opens the way for the generation of small libraries of heterocyclic nucleoside analogues for biological screening.

摘要

通过固相有机合成构建了一个尿嘧啶N1连接异恶唑、异恶唑啉和三唑以及尿嘧啶N3连接异恶唑啉和异恶唑的杂环核苷类似物库。该策略为生成用于生物筛选的杂环核苷类似物小型库开辟了道路。