志贺毒素在正常和发炎的人类肠道黏膜中的结合

Shiga toxin binding in normal and inflamed human intestinal mucosa.

作者信息

Schüller Stephanie, Heuschkel Robert, Torrente Franco, Kaper James B, Phillips Alan D

机构信息

Centre for Paediatric Gastroenterology, Royal Free & University College Medical School, Rowland Hill Street, London NW3 2PF, UK.

出版信息

Microbes Infect. 2007 Jan;9(1):35-9. doi: 10.1016/j.micinf.2006.10.005. Epub 2006 Dec 15.

DOI:10.1016/j.micinf.2006.10.005

PMID:17208032

Abstract

Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.

摘要

志贺毒素与溶血尿毒综合征相关，但人类肠道上皮细胞不表达Gb3受体。我们描述了组织学正常肠道中Gb3的表达和志贺毒素的结合，并证明在炎症性疾病状态下这种模式未改变。在正常和发炎黏膜的潘氏细胞中均鉴定出Gb3表达和志贺毒素结合。