Karakida T, Sakai M, Ito S, Yamada Y, Homma S
Department of Physiology, Niigata University School of Medicine, Japan.
Neurosci Lett. 1991 Aug 19;129(2):173-6. doi: 10.1016/0304-3940(91)90454-2.
Substance P and somatostatin contents were measured in the gastrointestinal tract of streptozotocin diabetic rats, 1 month after streptozotocin administration (60 mg/kg), and of age-matched controls with radioimmunoassay. Substance P and somatostatin contents were statistically increased in the extrafundus of the diabetic stomach, but not in the diabetic fundus. Substance P was significantly decreased in the diabetic ileum and caecum. Similarly, somatostatin was decreased in the diabetic caecum. Contrarily, slight increase of somatostatin contents in the diabetic duodenum, jejunum and proximal colon was not statistically significant.
用放射免疫分析法测定了链脲佐菌素糖尿病大鼠在给予链脲佐菌素（60毫克/千克）1个月后的胃肠道中P物质和生长抑素的含量，并与年龄匹配的对照组进行了比较。糖尿病胃的胃底外区域中P物质和生长抑素的含量在统计学上有所增加，但胃底中未增加。糖尿病回肠和盲肠中的P物质显著减少。同样，糖尿病盲肠中的生长抑素也减少。相反，糖尿病十二指肠、空肠和近端结肠中生长抑素含量的轻微增加在统计学上不显著。
