Tsunogake S, Nagashima S, Maekawa R, Takano N, Kajitani H, Saito K, Enokihara H, Furusawa S, Shishido H
Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Int J Hematol. 1991 Jun;54(3):251-6.
A 17-year-old male with congenital cyclic neutropenia was treated with recombinant human granulocyte colony stimulating factor (G-CSF) administered subcutaneously at 1 to 2 micrograms/kg per day. The peak and nadir counts of neutrophils and the peak counts of monocytes were significantly elevated, and the period of cycling decreased from 3 to 2 weeks. Bone marrow culture studies revealed the following abnormalities in granulocytic progenitor cells (CFU-G): a decrease in the concentrations of G-cluster forming cells, stimulated by a maximal dose of G-CSF, and a tendency of abnormally low responsive growth of the CFU-G to lower concentrations of G-CSF and GM-CSF. Our findings suggest that administration of G-CSF at relatively low doses overcomes or compensates for these abnormalities, though not completely, as fluctuation in the neutrophil counts persisted.
一名患有先天性周期性中性粒细胞减少症的17岁男性，接受了重组人粒细胞集落刺激因子（G-CSF）治疗，每天皮下注射1至2微克/千克。中性粒细胞的峰值和谷值计数以及单核细胞的峰值计数显著升高，循环周期从3周缩短至2周。骨髓培养研究显示粒细胞祖细胞（CFU-G）存在以下异常：最大剂量G-CSF刺激下G集落形成细胞浓度降低，CFU-G对较低浓度G-CSF和GM-CSF的反应性生长异常低。我们的研究结果表明，以相对低剂量施用G-CSF可克服或补偿这些异常，尽管并不完全，因为中性粒细胞计数仍有波动。
