Jadhav Vikram, Solaroglu Ihsan, Obenaus Andre, Zhang John H
Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.
Surg Neurol. 2007 Jan;67(1):15-20; discussion 20. doi: 10.1016/j.surneu.2006.07.014.
Neurosurgical procedures are carried out routinely in health institutions across the world. A key issue to be considered during neurosurgical interventions is that there is always an element of inevitable brain injury that results from the procedure itself because of the unique nature of the nervous system. Brain tissue at the periphery of the operative site is at risk of injury by various means, including incisions and direct trauma, electrocautery, hemorrhage, and retractor stretch.
METHODS/RESULTS: In the present review, we will elaborate upon this surgically induced brain injury and also present a novel animal model to study it. In addition, we will summarize preliminary results obtained by pretreatment with PP1, an Src tyrosine kinase inhibitor reported to have neuroprotective properties in in vivo experimental studies. Any form of pretreatment to limit the damage to the susceptible functional brain tissue during neurosurgical procedures may have a significant impact on patient recovery.
This brief review is intended to raise the question of 'neuroprotection against surgically induced brain injury' in the neurosurgical scientific community and stimulate discussions.
神经外科手术在世界各地的医疗机构中常规开展。神经外科手术干预过程中需要考虑的一个关键问题是，由于神经系统的独特性质，手术本身总会不可避免地造成一定程度的脑损伤。手术部位周边的脑组织会因各种方式面临损伤风险，包括切口和直接创伤、电灼、出血以及牵开器牵拉。
方法/结果：在本综述中，我们将详细阐述这种手术诱发的脑损伤，并介绍一种用于研究它的新型动物模型。此外，我们将总结通过用PP1进行预处理所获得的初步结果，PP1是一种Src酪氨酸激酶抑制剂，在体内实验研究中据报道具有神经保护特性。在神经外科手术过程中，任何形式的预处理以限制对易损功能性脑组织的损伤，都可能对患者恢复产生重大影响。
本简要综述旨在在神经外科学界提出“针对手术诱发脑损伤的神经保护”这一问题，并激发讨论。
