辅酶Q10对慢性耳鸣影响的一项试点临床试验。
A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium.
作者信息
Khan Martin, Gross Johann, Haupt Heidemarie, Jainz Annett, Niklowitz Petra, Scherer Hans, Schmidt Frank-Peter, Klapp Burghard F, Reisshauer Anett, Mazurek Birgit
机构信息
Department of Otorhinolaryngology, Charité-University Medicine Berlin, Berlin, Germany.
出版信息
Otolaryngol Head Neck Surg. 2007 Jan;136(1):72-7. doi: 10.1016/j.otohns.2006.07.010.
OBJECTIVE
To determine the short-term effects of coenzyme Q10 (CoQ10) on the antioxidative status and tinnitus expression in patients with chronic tinnitus aurium.
STUDY DESIGN
A 16-week prospective nonrandomized clinical trial (n = 20). Tinnitus and Short Form-36 Questionnaires (TQ/SF-36) were evaluated together with the plasma concentrations of CoQ10, malondialdehyde, and the total antioxidant status.
RESULTS
The mean plasma CoQ10 concentration rose under external CoQ10 supply and remained elevated after medication stopped without overall effects on the tinnitus score. However, in a subgroup of 7 patients with low initial plasma CoQ10 concentration and significant increase in the plasma CoQ10 level, a clear decrease in the TQ score was observed.
CONCLUSION
In patients with a low plasma CoQ10 concentration, CoQ10 supply may decrease the tinnitus expression.
SIGNIFICANCE
This is the first study to examine the effect of CoQ10 in chronic tinnitus aurium.
目的
确定辅酶Q10（CoQ10）对慢性耳鸣患者抗氧化状态和耳鸣表现的短期影响。
研究设计
一项为期16周的前瞻性非随机临床试验（n = 20）。对耳鸣和简短健康调查问卷（TQ/SF-36）以及血浆CoQ10、丙二醛和总抗氧化状态进行评估。
结果
在外部补充CoQ10的情况下，血浆CoQ10平均浓度升高，停药后仍保持升高，且对耳鸣评分无总体影响。然而，在7例初始血浆CoQ10浓度较低且血浆CoQ10水平显著升高的亚组患者中，观察到TQ评分明显下降。
结论
在血浆CoQ10浓度较低的患者中，补充CoQ10可能会降低耳鸣表现。
意义
这是第一项研究CoQ10对慢性耳鸣影响的研究。
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