Tikellis Gabriella, Sun Cong, Gorin Michael B, Klein Ronald, Klein Barbara E K, Larsen Emily K Marino, Siscovick David S, Hubbard Larry D, Wong Tien Y
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia.
Arch Ophthalmol. 2007 Jan;125(1):68-73. doi: 10.1001/archopht.125.1.68.
To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population.
Two thousand one hundred seventy persons 65 years and older sampled from 4 US communities had ARM signs assessed from retinal photographs using a modified Wisconsin Age-Related Maculopathy Grading System. DNA extracted from blood samples was analyzed for common APOE alleles.
After controlling for age, sex, cigarette smoking, and other factors, white participants carrying the epsilon2 allele had an increased risk of late ARM (odds ratio, 2.53 [95% confidence interval, 1.08-5.90]) while carriers of the epsilon4 allele had a lower risk of late ARM (odds ratio, 0.69 [95% confidence interval, 0.19-2.50]). There were too few late ARM cases in African American individuals for analysis.
APOE polymorphism is associated with late ARM in older white persons 65 years and older. Consistent with previous studies, the APOE epsilon2 allele is associated with a significant increased risk of late ARM development, whereas the epsilon4 allele may confer some protection.
在老年人群中研究载脂蛋白E（APOE）基因与年龄相关性黄斑病变（ARM）之间的关联。
从美国4个社区抽取2170名65岁及以上的老年人，使用改良的威斯康星年龄相关性黄斑病变分级系统，根据视网膜照片评估ARM体征。对血样提取的DNA进行常见APOE等位基因分析。
在对年龄、性别、吸烟及其他因素进行控制后，携带ε2等位基因的白人参与者发生晚期ARM的风险增加（比值比，2.53[95%置信区间，1.08 - 5.90]），而携带ε4等位基因者发生晚期ARM的风险较低（比值比，0.69[95%置信区间，0.19 - 2.50]）。非裔美国人中晚期ARM病例过少，无法进行分析。
APOE基因多态性与65岁及以上老年白人的晚期ARM相关。与先前研究一致，APOE ε2等位基因与晚期ARM发生风险显著增加相关，而ε4等位基因可能具有一定保护作用。
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