[人非小细胞肺癌中HLA I类分子异常表达的组织芯片分析]

[Tissue array analysis of the aberrant expression of HLA class I molecules in human non small cell lung cancer].

作者信息

Suzuki Hiroyuki, Higuchi Mitsunori, Hasegawa Takeo, Yonechi Atsushi, Ohsugi Jun, Yamada Fumihiko, Hoshino Mika, Shio Yutaka, Fujiu Koichi, Gotoh Mitsukazu

机构信息

Dept. of Surgery I, Fukushima Medical University.

出版信息

Gan To Kagaku Ryoho. 2006 Nov;33(12):1713-6.

PMID:17212084

Abstract

A clinical significance of the aberrant expression of HLA class I molecules including HLA class I and HLA-G was analyzed using tissue array analysis. Our institute has established a two millimeter spot sized tissue array set of 105 clinical cases of resected human non small cell lung cancer tissues. A loss of HLA class I was observed in the 58.3% of cancer tissues. The aberrant expression of HLA G was also observed in the 55.2% of cancer tissues. Statistically significant correlations were observed among HLA class I expression and tumor size, nodal involvement and pathological stage. Survival analyses were shown that the HLA class I loss was correlated to a recurrence free survival time. The HLA-G expression did not correlate with any clinico-pathological parameters. A loss of HLA class I was probably involved due to a cancer progression in human non-small cell lung cancer through the mechanism of immune escape from the host immune system.

摘要

利用组织芯片分析技术，对包括HLA - I类分子（HLA - I和HLA - G）异常表达的临床意义进行了分析。我们研究所建立了一套由105例切除的人类非小细胞肺癌组织构成的两毫米斑点大小的组织芯片组。在58.3%的癌组织中观察到HLA - I类分子缺失。在55.2%的癌组织中也观察到HLA - G的异常表达。在HLA - I类分子表达与肿瘤大小、淋巴结受累情况及病理分期之间观察到具有统计学意义的相关性。生存分析表明，HLA - I类分子缺失与无复发生存时间相关。HLA - G表达与任何临床病理参数均无相关性。人类非小细胞肺癌中HLA - I类分子缺失可能是由于肿瘤进展通过逃避宿主免疫系统的免疫逃逸机制所致。