Lécureuil Charlotte, Kara Elodie, Guillou Florian, Monniaux Danielle, Crépieux Pascale
Physiologie de la Reproduction et des Comportements, UMR 6175 INRA-CNRS-Université de Tours-Haras Nationaux-IFR 135, 37380 Nouzilly, France.
Med Sci (Paris). 2007 Jan;23(1):75-80. doi: 10.1051/medsci/200723175.
FSH is the main endocrine control of mammalian reproduction. FSH triggers somatic cells of the gonads which support germ cells metabolically, i.e. Sertoli cells of the seminiferous tubules, and granulosa cells harboring the oocyte, within the ovarian follicle. FSH leads to similar biological responses in both cell types since it stimulates proliferation and differentiation, according to the developmental stage. However, FSH receptor knock-out female mice are infertile, unlike male mice. Hence, FSH is not equally important in both sexes. Nevertheless, does FSH induce distinct signalling mechanisms in its target cells ? Here, we compare the signalling mechanisms induced by FSH in ovarian and testicular physiology.
促卵泡激素（FSH）是哺乳动物生殖的主要内分泌调控因子。FSH作用于性腺的体细胞，这些体细胞为生殖细胞提供代谢支持，即生精小管中的支持细胞，以及卵巢卵泡内包裹卵母细胞的颗粒细胞。由于FSH根据发育阶段刺激细胞增殖和分化，它在这两种细胞类型中引发相似的生物学反应。然而，与雄性小鼠不同，促卵泡激素受体敲除的雌性小鼠不育。因此，FSH在两性中的重要性并不相同。那么，FSH在其靶细胞中是否诱导不同的信号传导机制呢？在这里，我们比较了FSH在卵巢和睾丸生理中诱导的信号传导机制。
