Effect of FK 506 on FK-binding protein and transforming growth factor beta gene expression.
作者信息
Rao P, Sun H, Snyder J, Fung J J, Starzl T E
机构信息
Department of Surgery, University of Pittsburgh, Pennsylvania 15213.
出版信息
Transplant Proc. 1991 Dec;23(6):2873-4.
Abstract
摘要
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Effect of FK 506 on FK-binding protein and transforming growth factor beta gene expression.FK506对FK结合蛋白和转化生长因子β基因表达的影响。
Transplant Proc. 1991 Dec;23(6):2873-4.
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Induction of liver, heart, and multivisceral graft acceptance with a short course of FK 506.采用短期FK 506诱导肝脏、心脏和多脏器移植受者的移植物耐受。
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Mechanisms of immunosuppressive effects of FK 506 in light of apoptosis of hepatocytes and infiltrating lymphocytes in rat allografted livers.从大鼠同种异体移植肝脏中肝细胞和浸润淋巴细胞凋亡角度探讨FK 506免疫抑制作用的机制。
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TGF-beta expression in protocol transplant liver biopsies: a comparative study between cyclosporine-A (CyA) and tacrolimus (FK 506) immunosuppression.方案移植肝活检中转化生长因子-β的表达：环孢素A（CyA）与他克莫司（FK 506）免疫抑制作用的比较研究
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Establishment of chimerism in donors by intraportal injection of recipient-type bone marrow cells with concomitant administration of FK 506 before liver transplantation prolongs liver allograft survival in rats.肝移植前通过门静脉注射受体型骨髓细胞并同时给予FK 506在供体中建立嵌合状态可延长大鼠肝移植存活时间。
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Hepatocytes or liver nonparenchymal cells plus FK 506 prolong liver xenograft survival.肝细胞或肝脏非实质细胞加FK 506可延长肝脏异种移植的存活时间。
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引用本文的文献
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Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation.他克莫司。其药理学及在肝移植和肾移植中的治疗潜力综述。
Drugs. 1993 Oct;46(4):746-94. doi: 10.2165/00003495-199346040-00009.
本文引用的文献
1
Cyclophilin: a specific cytosolic binding protein for cyclosporin A.亲环蛋白：一种环孢菌素A的特异性胞质结合蛋白。
Science. 1984 Nov 2;226(4674):544-7. doi: 10.1126/science.6238408.
2
The effects of cyclosporin A on the immune system.环孢素A对免疫系统的影响。
Annu Rev Immunol. 1985;3:397-423. doi: 10.1146/annurev.iy.03.040185.002145.
3
Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.转化生长因子β对细胞毒性T细胞发育的抑制作用及重组肿瘤坏死因子α的逆转作用。
J Exp Med. 1987 Oct 1;166(4):991-8. doi: 10.1084/jem.166.4.991.
4
Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.环孢菌素A和转化生长因子β对细胞因子产生的抑制作用
J Exp Med. 1987 Aug 1;166(2):571-6. doi: 10.1084/jem.166.2.571.
5
Transforming growth factor-beta s are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation.转化生长因子-β是白细胞介素-1诱导的胸腺细胞增殖的等效生长抑制剂。
Cell Immunol. 1988 Jun;114(1):41-54. doi: 10.1016/0008-8749(88)90253-5.
6
Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.人T淋巴细胞转化生长因子β的产生及其在T细胞生长调节中的潜在作用。
J Exp Med. 1986 May 1;163(5):1037-50. doi: 10.1084/jem.163.5.1037.
7
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin.肽基脯氨酰顺反异构酶是环孢菌素A结合蛋白亲环蛋白。
Nature. 1989 Feb 2;337(6206):473-5. doi: 10.1038/337473a0.
8
Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins.亲环蛋白和肽基脯氨酰顺反异构酶可能是同一蛋白质。
Nature. 1989 Feb 2;337(6206):476-8. doi: 10.1038/337476a0.
9
FK 506 for liver, kidney, and pancreas transplantation.用于肝脏、肾脏和胰腺移植的FK 506。
Lancet. 1989 Oct 28;2(8670):1000-4. doi: 10.1016/s0140-6736(89)91014-3.
10
A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase.免疫抑制剂FK506的一种受体是一种顺反肽基脯氨酰异构酶。
Nature. 1989 Oct 26;341(6244):758-60. doi: 10.1038/341758a0.
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