在喉癌中，乳腺丝抑蛋白的核定位与肿瘤相关微血管密度降低有关。

Maspin nuclear localization is related to reduced density of tumour-associated micro-vessels in laryngeal carcinoma.

作者信息

Marioni Gino, D'Alessandro Emiliano, Giacomelli Luciano, De Filippis Cosimo, Calgaro Nicola, Sari Marianna, Staffieri Alberto, Blandamura Stella

机构信息

Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padova, Italy.

出版信息

Anticancer Res. 2006 Nov-Dec;26(6C):4927-32.

PMID:17214364

Abstract

BACKGROUND

MASPIN, a tumour suppressing serpin, is a potent inhibitor of angiogenesis. CD105 is a proliferation-associated protein acting in endothelial cells of angiogenic tissues. For the first time the relation between nuclear MASPIN expression and CD105-assessed micro-vessel density (MVD) in laryngeal carcinoma was investigated.

PATIENTS AND METHODS

The sub-cellular distribution of MASPIN and nuclear MASPIN expression were immunohistochemically determined in 35 cases of laryngeal carcinoma. The percentage of the fields occupied by CDl05-assessed micro-vessels was also calculated.

RESULTS

MVD was significantly lower in laryngeal carcinomas with MASPIN nuclear staining than in carcinomas with cytoplasmic staining (p=0.02). The mean nuclear MASPIN expression was higher in patients without carcinoma recurrence than in those with recurrence (p=0.06). The mean MVD was significantly higher in patients with recurrence of carcinoma (p=0.024).

CONCLUSION

The crucial role of MASPIN nuclear localization in reducing the MVD has been demonstrated. Nuclear MASPIN re-expression should be investigated as a potential therapeutic option in the treatment of laryngeal carcinoma.

摘要