Marioni G, Ottaviano G, Giacomelli L, Staffieri C, Casarotti-Todeschini S, Bonandini E, Staffieri A, Blandamura S
Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Via Giustiniani 2, 35100 Padova, Italy.
Eur J Surg Oncol. 2006 Dec;32(10):1149-53. doi: 10.1016/j.ejso.2006.08.001. Epub 2006 Sep 18.
Angiogenesis is essential for malignancies growth. CD105 is a proliferation-associated protein abundantly expressed in angiogenic endothelial cells. The aim of this study has been to determine the expression of CD105 in laryngeal squamous cell carcinoma (SCC) and to investigate the role of CD105-assessed mean vascular density (MVD) in predicting patients' prognosis.
The sections of 43 consecutive cases of laryngeal SCC were stained with mouse monoclonal antibody CD105. All the measures were performed by a computer-based image analysis system. The percentage of the fields occupied by CD105-assessed micro-vessels was determined.
The mean CD105-assessed MVD were 11% and 6% in laryngeal SCC with and without malignancy recurrence, respectively. Multivariate logistic regression stated that CD105-assessed MVD was significantly related to disease recurrence (p=0.030).
Our preliminary results suggest that CD105-assessed MVD may be a valuable parameter for predicting patients having an increased risk of developing laryngeal carcinoma loco-regional recurrence.
血管生成对恶性肿瘤的生长至关重要。CD105是一种在血管生成内皮细胞中大量表达的增殖相关蛋白。本研究的目的是确定CD105在喉鳞状细胞癌（SCC）中的表达，并研究通过CD105评估的平均血管密度（MVD）在预测患者预后中的作用。
对43例连续的喉SCC病例切片用小鼠单克隆抗体CD105进行染色。所有测量均通过基于计算机的图像分析系统进行。确定CD105评估的微血管所占视野的百分比。
在有和无恶性肿瘤复发的喉SCC中，通过CD105评估的平均MVD分别为11%和6%。多因素逻辑回归表明，通过CD105评估的MVD与疾病复发显著相关（p = 0.030）。
我们的初步结果表明，通过CD105评估的MVD可能是预测喉癌局部区域复发风险增加患者的一个有价值的参数。
