Takeoka Yasunobu, Nakamae Mika, Nakamae Hirohisa, Hagihara Kiyoyuki, Sakamoto Erina, Nakane Takahiko, Koh Hideo, Koh Ki-Ryang, Ohta Kensuke, Yamane Takahisa, Hino Masayuki
Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Acta Haematol. 2007;117(4):205-10. doi: 10.1159/000098461. Epub 2007 Jan 11.
There have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with hemophagocytic lymphohistiocytosis (HLH). In both of the patients, ventricular dysfunction suddenly occurred during the active phase of HLH. In each case, the findings on ECG, echocardiogram and left ventriculogram were compatible with ampulla cardiomyopathy. To our knowledge, this communication is the first to report cases of ampulla cardiomyopathy associated with HLH. Our cases suggest that HLH hypercytokinemia may have a role in causing ampulla cardiomyopathy.
在心血管领域，有许多关于壶腹型心肌病患者被描述为Takotsubo型心肌病的报道。这种独特的心肌病的特征是左心室短暂的心尖部气球样变和运动减弱。我们描述了2例与噬血细胞性淋巴组织细胞增生症（HLH）相关的壶腹型心肌病病例。在这两名患者中，心室功能障碍均在HLH活动期突然发生。在每个病例中，心电图、超声心动图和左心室造影的结果均与壶腹型心肌病相符。据我们所知，本报告是首次报道与HLH相关的壶腹型心肌病病例。我们的病例提示HLH高细胞因子血症可能在导致壶腹型心肌病中起作用。
