充满泪水的关系？性、激素、泪腺与水液缺乏型干眼。

Tearful relationships? Sex, hormones, the lacrimal gland, and aqueous-deficient dry eye.

作者信息

Sullivan David A

机构信息

Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA.

出版信息

Ocul Surf. 2004 Apr;2(2):92-123. doi: 10.1016/s1542-0124(12)70147-7.

DOI:10.1016/s1542-0124(12)70147-7

PMID:17216082

Abstract

Sex and the endocrine system exert a significant influence on the physiology and pathophysiology of the lacrimal gland. The purpose of this article is to briefly review the nature and magnitude of these interactions between sex, hormones and lacrimal tissue, and to address how they may relate to the pathogenesis of aqueous-deficient dry eye. Towards this end, this article has a 3-fold approach: first, to summarize the influence of androgens, estrogens, glucocorticoids, mineralocorticoids, retinoic acid, prolactin, alpha-melanocyte stimulating hormone, adrenocorticotropic hormone, luteinizing hormone, follicle-stimulating hormone, growth hormone, thyroid-stimulating hormone, arginine vasopressin, oxytocin, thyroxine, parathyroid hormone, insulin, glucagon, melatonin, human chorionic gonadotropin and cholecystokinin on the structure and function of the lacrimal gland; second, to discuss the mechanism of action of each hormone on lacrimal tissue; and third, to discuss the clinical relevance of the endocrine-lacrimal gland interrelationship, with a particular focus on each hormone's role (i.e. if relevant) in the development of aqueous-tear deficiency.

摘要

性别和内分泌系统对泪腺的生理及病理生理有着重大影响。本文旨在简要回顾性别、激素与泪腺组织之间这些相互作用的性质和程度，并探讨它们与水液缺乏型干眼发病机制的关联。为此，本文采用了三方面的方法：第一，总结雄激素、雌激素、糖皮质激素、盐皮质激素、视黄酸、催乳素、α-黑素细胞刺激素、促肾上腺皮质激素、黄体生成素、卵泡刺激素、生长激素、促甲状腺激素、精氨酸加压素、催产素、甲状腺素、甲状旁腺激素、胰岛素、胰高血糖素、褪黑素、人绒毛膜促性腺激素和胆囊收缩素对泪腺结构和功能的影响；第二，讨论每种激素对泪腺组织的作用机制；第三，讨论内分泌与泪腺相互关系的临床相关性，特别关注每种激素（如相关）在水液性泪液缺乏发生发展中的作用。