Stegger Lars, Lipke Claudia S A, Kies Peter, Nowak Bernd, Schober Otmar, Buell Udalrich, Schäfers Michael, Schaefer Wolfgang M
Department of Nuclear Medicine, University Hospital, Westfälische Wilhelms-University Münster, Münster, Germany.
Eur J Nucl Med Mol Imaging. 2007 Jun;34(6):900-9. doi: 10.1007/s00259-006-0322-0. Epub 2007 Jan 10.
The segmentation algorithm ESM based on an elastic surface model was validated for the assessment of left ventricular volumes and ejection fraction from ECG-gated myocardial perfusion SPECT. Additionally, it was compared with the commercially available quantification packages 4D-MSPECT and QGS. Cardiac MRI was used as the reference method.
SPECT and MRI were performed on 70 consecutive patients with suspected or proven coronary artery disease. End-diastolic (EDV) and end-systolic (ESV) volumes and left ventricular ejection fraction (LVEF) were derived from SPECT studies by using the segmentation algorithms ESM, 4D-MSPECT and QGS and from cardiac MRI.
ESM-derived values for EDV and ESV correlated well with those from cardiac MRI (correlation coefficients R=0.90 and R=0.95, respectively), as did the measurements for LVEF (R=0.86). Both EDV and ESV were slightly overestimated for larger ventricles but not for smaller ventricles; LVEF was slightly overestimated irrespective of ventricle size. The above correlation coefficients are comparable to those for the 4D-MSPECT and QGS segmentation algorithms. However, results obtained with the three segmentation algorithms are not interchangeable.
The ESM algorithm can be used to assess EDV, ESV and LVEF from gated perfusion SPECT images. Overall, the performance was similar to that of 4D-MSPECT and QGS when compared with cardiac MRI. Results obtained with the three tested segmentation methods are not interchangeable, so that the same algorithm should be used for follow-up studies and control subjects.
验证基于弹性表面模型的分割算法ESM用于评估心电图门控心肌灌注单光子发射计算机断层扫描（SPECT）中的左心室容积和射血分数。此外，将其与市售的定量软件包4D-MSPECT和QGS进行比较。心脏磁共振成像（MRI）用作参考方法。
对70例连续的疑似或确诊为冠状动脉疾病的患者进行SPECT和MRI检查。通过使用分割算法ESM、4D-MSPECT和QGS以及心脏MRI从SPECT研究中得出舒张末期（EDV）和收缩末期（ESV）容积以及左心室射血分数（LVEF）。
ESM得出的EDV和ESV值与心脏MRI得出的值具有良好的相关性（相关系数分别为R = 0.90和R = 0.95），LVEF的测量值也是如此（R = 0.86）。对于较大的心室，EDV和ESV均略有高估，但对于较小的心室则不然；无论心室大小如何，LVEF均略有高估。上述相关系数与4D-MSPECT和QGS分割算法的相关系数相当。然而，用这三种分割算法获得的结果不可互换。
ESM算法可用于从门控灌注SPECT图像评估EDV、ESV和LVEF。总体而言，与心脏MRI相比，其性能与4D-MSPECT和QGS相似。用三种测试分割方法获得的结果不可互换，因此在后续研究和对照对象中应使用相同的算法。
